Day 1 :
- Healthcare and Innovation
Zsolt P. Ori
Ori Diagnostic Instruments, USA
Title: Reaching for Cardio-Metabolic Fitness and Resilience through Self-Healing and Cyber-Therapy â€“ an Opportunity to Reenergize Primary Care
Zsolt P. Ori is a practicing internist, primary physician and hospitalist with previous training in Bio-Medical Cybernetics (Ilmenau University of Technology, Germany) before entering medical school (Albert Szent-Györgyi Medical School , Szeged, Hungary) and post-doctoral research fellowship in non-invasive cardiology (Northwestern University, Chicago) . His engineering training together with his experiences in primary care in academic and non-academic environments have inspired his vision for using Cybernetics to improve cardiometabolic health with result driven predictive feedback control. His patented inventions can build a bridge between sensory data from wearables and plug the data into physiological process models and make the otherwise undetectable slow changes of the energy metabolism observable and derive easily readable trend indicators allowing for stepwise dynamic behavior control for reaching cardiometabolic health and mental resilience. CPS derived data can provide metrics facilitating education about metabolic health as well as to reach community health, corporate health and public health goals.
There is a need to facilitate efforts to reduce cardiovascular risks such as insulin resistance with healthy lifestyle and to improve cardiometabolic fitness, resilience and longevity with both self-management and guided therapy. To facilitate this process, we recently introduced a Cyber-Physical System (CPS) [4-5]. CPS is a mobile technology integrating sensory data from various mobile devices into individualized dynamic mathematical models of physiological processes allowing for analysis, prediction and maximizing control by user and potentially supported also by machine learning. We invented self-adjusting mathematical models [1-3], allowing for the noninvasive observation of insulin resistance changes by R- or Rw-ratio. We were able to prove the feasibility of our modelling concept of the insulin resistance by finding strong correlation ρ= -0.6745, P=0.000024 between changes of Rw-ratio and insulin resistance HOMA-IR in 12 clinical studies with 39 clinical study arms as in Figure 1. Based on these results we found that CPS is a suitable concept to indirectly measure and predict the otherwise very difficult- or impossible-to-measure slow changes of state variables (SV’s) of the metabolism such as 24h nonprotein respiratory quotient, utilized macronutrient energies, fat oxidation rate, carbohydrate oxidation rates, de novo lipogenesis, and adaptive thermogenesis and capture them for the first time noninvasively in the user’s natural environment. Serial fat and weight measurements and energy calculations can help unmask changes of insulin resistance in response to user’s diet and exercise habits, creating the necessary environment to measure metabolic flexibility. The feedback of individualized metrics using tools of the digital health era may amount to channeling focus also to patient-centered individualized care and to accelerating nutrition research. In conclusion, CPS can serve as an appropriate real-time tool to monitor and optimally adjust modifiable risk factors, allowing for planning and executing dynamic changes of behavior for optimization and control of metabolic SV’s.
Liberty University, USA
Title: Introducing the Sorush Cancer Treatment Protocol (SCTP)
Sorush Niknamian PhD CRFM PE APA_FPD AICP MWSES MLPI MACRO MTMA MRSB FIMS FChE EMBS FNNECOS FTSCO ANCC, AANP, ACPE, ACHE, ADA CERP APA FMDCSCO FSASS) Ph.D. in Cell and Molecular Biology and Oncology and Professor of Cell and Molecular Biology, Oncology and Biological Attacks. He is a Professional Biologist, Senior Research Scientist, Chartered Scientist and Registered His Science Council ID is: A-0008833. He is one of United Kingdom and Indiana Cancer Consortium (ICC) certified. He is a Registered Researcher in the U.S. Government's System for Award Management, Registered Scientist at National Center for Biotechnology Information. He is studying Medicine/Military Medicine at Liberty University (LU), Lynchburg, VA, United States of America. He holds Bachelor’s Degree in Mechatronics Engineering, applied Mathematics, Civil Engineering and Management. He is a Member of US Government National Science Foundation, Member of Hera Swiss Volunteers (ID: 198036), Member of US Army American College of Physicians Chapter, Ambassador of American Cancer Society (ACS CAN) and former Ambassador of European Association for Cancer Research (EACR), Active Member of Federal Health Professionals at US Army Forces and Certified Member of American Red Cross and Food Regulatory Affairs Professionals. He is an Honorary Board Member and contributor of Weston A Price Foundation (WAPF) in Washington DC, United States of America. He Holds Honorary Doctorate of Cancer Biology and Doctor of Science from Violet Cancer Institute. He is preserved and nominated for the preserved as Position Title: DIRECTOR OF MILITARY SUPPORT, Agency: Army National Guard Units. Announcement Number: ID: WA-10507254-AR-19-161. Extra Information: DIRECTOR OF MILITARY SUPPORT located at the WASHINGTON J3 DCSOPS. Professor Sorush Niknamian is an ACP Chapter member in United States Army and Air Force. Active Member of IMRTC-USA (International Management Research and Technology Consortium Research) as Advisor, Referee and Professor at IMRTC-USA (International Management Research and Technology Consortium Panel). He is a Service Member of Modern Military Association of America. Certified Member of World Medical Association with ID: 5c7b154b01602 as a Junior Medical Doctor. He is an Active Member of the National Guard Association of the United States of America (Branch: Army, Rank: Major, State Affiliation: Maryland) and Serving Volunteer at the Peace Corps of the United States of America (Ref ID: 10811430) and certified member of The National Bureau of Asian Research. He is a member of Military Officers Association of America (Member Number: 05670401, Rank: Major). He is one of the certified member of Texas Section of the American Physical Society. Active Member of the United Nation (ROSTER NUMBER – 1665156). MAJ Dr. Sorush Niknamian is a Certified and professional in Terrorism Affairs, Terrorism Analysis and Terrorism Counterterrorism from American Military University (AMU). He has been written more than 30 books in different area of science specially Medicine, Evolutionary Biology, Nutrition and Oncology. He has published more than 120 research articles in International and National scientific journals. He is an activist in ASCO Action Network in Virginia. He is an active Member of Physicians for human rights. He is an active member of Federal Planners' Advocacy Network.
This research introduces Sorush Cancer Treatment Ptotocol (SCTP) based on successful cancer treatment methodology which has done by Dr. Somayeh Zaminpira and Dr. Sorush Niknamian in 54 cancer patients in Violet Cancer Institute (VCI), Combining Specific Ketogenic Diet (SKD)- which has 80% saturated fat, 15% Protein with the lowest glutamine and 5% complex-high fiber carbohydrate- and intravenous ozone therapy which has had marvelous results in the treatment of several cancers in human models. The aim of this protocol is to weaken and starve cancer cells, decreasing acidity, increasing the immune system response, decreasing the possibility of metastasis and decreasing the cachexia without any serious side effects in cancer patients. This protocol introduces mega vitamins and minerals plus several supplements based on some tried and true protocols mainly the Budwig and Bill Henderson Protocol (BHP) with serious revisions. The BHP incorporates principal components of the Budwig Diet which was developed in the early 1950s by German chemist Dr. Johanna Budwig (1908–2003). Budwig’s theory is based upon the work of Otto Warburg (1883–1970). Warburg was an earlier Nobel Prize Laureate (1931) for the discovery of the nature and action of the respiratory enzyme, the first of the so-called yellow enzymes, or flavoproteins. Warburg’s scientific efforts produced a large body of work and publications in highly respected journals such as Science (1928, 1956). According to Budwig, Warburg theorized that cellular respiration, like many chemical reactions, was dependent upon substrate availability, specifically a sulphydryl group and an unknown saturated fatty acid, which he failed to identify. According to Dr. S. Zaminpira and Dr. S. Niknamian, Cancer is an Evolutionary Metabolic disease (EMHC) and the main cause of cancer is the Butterfly Effect inside normal cells as a result of increasing the amounts of Reactive Oxygen Species (ROS).
- Global Healthcare
Title: A role for heavy metal toxicity and air pollution in respiratory tract cancers
Chanda Siddoo-Atwal, completed her B.Sc. in Biochemistry from the University of London. Her Ph.D. was taken in Applied Sciences from Simon Fraser University in Burnaby (her research conducted at the BC Cancer Research Centre) and she did a Post-doctoral fellowship in the Biochemistry Department at the Medical College of Wisconsin. Cancer is her subject of specialization and started with research on Ataxia-telangiectasia (AT) patients, who are genetically prone to lymphomas. Since then, she has focussed mainly on mechanisms of carcinogenesis in various models including the AT disease state and ionizing radiation-induced cancer, mycotoxin-induced and chemically-induced cancers, microwave-induced cancers, and ultraviolet radiation-induced skin cancer. She is the President and Primary Biochemist of Moondust Cosmetics Ltd and her current research activity includes the formulation of a novel sunscreen to combat apoptotic sunburn that has been associated with skin cancer and other suncare products for the repair of skin damage related to sun exposure. She has been invited to present her research papers at conferences around the world and is the author of a recent book called, “A New Approach to Cancer Risk Assessment: An Overview” published by Lambert Academic Publishing. In addition, she has been asked to contribute chapters to textbooks by various international publishers including Springer and INTECH. Recently, she received a Drishti Award in recognition of her scientific contribution and commitment to education in the sunscreen industry.
Cigarette smoke and air pollution have been associated with lung cancer and nasopharyngeal and laryngeal cancer, respectively. Significant concentrations of select heavy metals including lead and cadmium have been isolated in popular cigarette brands and these heavy metals can be inhaled via smoking. Lead is able to mimic the activity of calcium in the human body thereby leading to toxic effects in a variety of target organs. These biochemical effects include the calcium-dependent inhibition of release of several neurotransmitters and augmentation of calcium-dependent events involving protein kinase C and calmodulin. Lead perturbs and alters the release of intracellular calcium stores from organelles like the endoplasmic reticulum (ER) and mitochondria. Mitochondrial calcium accumulation and resultant membrane depolarization due to its release have been linked to the initiation of a cell death pathway in mitochondria. A rise in mitochondrial calcium also stimulates the generation of reactive oxygen species (ROS) and free fatty acids which can further promote calcium release and, ultimately, result in cell death. In the case of cadmium, the renal proximal tubule of the kidney accumulates freely filtered and metallothionein bound metal, which is degraded in endosomes and lysosomes. This results in the release of free cadmium into the cytosol where it can generate reactive oxygen species and activate cell death pathways. In developing countries, indoor air pollution due to the domestic use of unprocessed biomass fuels such as wood, dung, and coal is another cause of respiratory tract cancers in humans. In some developed countries such as Australia and Canada, the alarming increase in forest fire frequency due to climate-change and the associated smoke released into the environment is also likely to pose a future human health risk. Polycyclic organic particles in biomass and forest fire smoke can include carcinogens such as benzo[a]pyrene, which is also found in cigarette smoke. Benzo[a]pyrene can induce apoptosis in mammalian cells by initiating mitochondrial dysfunction; activating the intrinsic caspase pathway (caspase-3 and caspase-9); and, via p53 activation. The constitutive activation of apoptotic pathways has been linked to carcinogenesis in a number of cancer models.
- Healthcare Administration
Director General at the Federal Senate, Brazil
Title: Social marketing and health communication: A case study at the brazilian federal senate
Ilana Trombka, Master degree in Public Relations at Pontifícia Universidade Católica do Rio Grande do Sul, Brazil. Director General - Chairwoman of the Board of Directors - of the Brazilian Federal Senate and Vice President of Board Council of the Senate`s Health Integrated System.
This presentation aims to show how a breast cancer campaign can be successfully planned and how the expected results can be achieved, in accordance with the best practices of health communication under the social marketing paradigm. The case study is the Pink October (month dedicated to women's health) at the Brazilian Federal Senate, in 2017, result of interdepartmental (Top Management, Health, Human Resources and Social Communication areas) and interinstitutional (Federal Senate, Government of the Federal District and health-related institutions) partnership efforts. Social marketing, internal marketing and endobranding concepts are explored, as well as the breast cancer issue, in order to provide a better understanding among interested readers. While results are positive, some challenges and concerns are brought to light, which point to the need for improvements in the Pink October program for the coming years. The case study involved literature review, analysis of media articles and focused interviews.
- Pediatric & Neonatal Healthcare
Simona Delia Nicoara
Emergency County Hospital, Cluj-Napoca, Romania
Title: Status of the laser treatment for Retinopathy of Prematurity in the anti-Vascular Endothelial Growth Factor era
Simona Delia Nicoara has her expertise in the medical and surgical treatment of retinal diseases. She introduced modern vitreo-retinal surgery in the Department of Ophthalmology belonging to “Iuliu Hatieganu” University of Medicine and Pharmacy, Emergency County Hospital from Cluj-Napoca. She also was the first to perform laser photocoagulation for ROP in the Department and the first anti-VEGF treatment for ROP in Romania. She coordinated 4 national research grants involving vitreo-retinal surgery, vitreo-retinal biomechanics and stem cell regeneration of the retina and optic nerve.
Statement of the Problem: Retinopathy of prematurity (ROP) is a preventable cause of childhood blindness related to premature birth. Most of ROP cases regress spontaneously. Approximately 10% of them are severe and lead to blindness if not treated promptly. The gold standard of care for ROP is laser photocoagulation of the non-vascularized retina. Over the last decade, a new therapeutic option has become available for ROP: intravitreal anti-VEGF injections. The purpose of this study is to describe the experience of our center in treating ROP with laser and/or intravitreal Bevacizumab IVB), with the aim of pointing out the current place of laser photocoagulation in the management of ROP. Methodology & Theoretical Orientation: All the consecutive infants with ROP who received treatment between 2006 - 2017and had at least one year follow up were included in the study. The main outcome measures were the recurrence and the complication rate. Statistical analysis was performed using Microsoft Excel and IBM SPSS software (version 21.0). In the classic form of ROP, the 2 methods showed similar outcomes regarding efficacy. However, in the most severe form of ROP, aggressive posterior ROP (AP-ROP), IVB has led to significantly better outcomes as compared to laser. Additionally, IVB is easier, shorter, nondestructive, requires topical anesthesia, eliminating the risk of general anesthesia in premature infants. Systemic complications related to IVB absorption are still debated, but no report was signaled so far. Within the IVB group, we identified no local complications and within the laser group we report 2 cases of mild anterior uveitis that resolved completely with topical treatment. Conclusion & Significance: IVB has become the first line of treatment in AP-ROP. Laser photocoagulation is the first therapeutic line in the classic form of ROP and in conjunction with IVB in AP-ROP cases that do not regress following IVB.